Jan Riemer

This study shows that ROS-induced oxidation of gephyrin cysteines promotes synaptic multimerization and enhances inhibitory receptor clustering through disulfide bridges.

The paper identifies AIFM1 as an OMA1 substrate that, when cleaved under mitochondrial stress, reduces OXPHOS activity and suppresses cell growth.

This paper structurally characterizes CCDC127 as a mitochondrial intermembrane space protein involved in the mitoskeleton framework.

The paper identifies CCDC127 as a mitochondrial disulfide relay substrate that interacts with MICOS components, revealing its role in OMM topology and mitochondrial membrane organization.

This study identifies FAM136A as a mitochondrial disulphide relay substrate essential for IMS proteostasis, showing its role in cellular fitness and stress response.

The paper identifies AIFM1's interaction with AK2A and shows how this stabilizes AK2A and enhances NADH oxidoreductase activity, highlighting AIFM1's role in energy metabolism.

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

This study identifies Tsa1 as the primary peroxide scavenger in yeast and shows it can generate GSSG under H2O2 conditions.

This study shows TRC40 switches from an ATP-dependent targeting factor to an ATP-independent chaperone under oxidative stress, preventing protein aggregation and supporting proteostasis.