Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders
Maia Lina Elizagaray, Ferran Barrachina, Maria Carolina Avenatti, Isinsu Bastepe, Angela Chen, Ainize Odriozola Larrañaga, Oluchi Ukairo, Vanina Gabriela Da Ros, Kiera Ottino, Nerea Subirán, María Agustina Battistone
This study shows that chronic inflammation in the epididymis leads to tertiary lymphoid structure formation and autoimmune fertility issues in mice, with similar autoantibodies found in human infertile patients.
Nature Communications · Oct 1, 2025Peer-reviewedImmunology