Author

Omar Hamdan

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetic & Genomic Medicine· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Bhooma ThiruvahindrapuramiD· 4 shared Giovanna PellecchiaiD· 3 shared Wilson W. L. SungiD· 3 shared Brett TrostiD· 2 shared Christian R. MarshalliD· 2 shared Delnaz RoshandeliD· 2 shared Jeffrey R. MacDonaldiD· 2 shared Joe WhitneyiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Bhooma ThiruvahindrapuramORCID

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4 papers

Recent·Most cited

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

Worrawat Engchuan, Omar Shanta, Kuldeep Kumar, Jeffrey R. MacDonald, Bhooma Thiruvahindrapuram, Omar Hamdan, Marieke Klein, Adam X. Maihofer, James Guevara, Oanh Hong, Guillaume Huguet, Molly Sacks, Mohammad Mehdi Ahangari, Rayssa M.M.W. Feitosa, Kara Han, , Michael Foster Green

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

medRxiv · Jul 11, 2025 · PreprintGenetic & Genomic Medicine

Genomic architecture of autism spectrum disorder from comprehensive whole-genome sequence annotation

Brett Trost, Bhooma Thiruvahindrapuram, Ada J. S. Chan, Worrawat Engchuan, Edward J. Higginbotham, Jennifer Howe, Livia Oliveira Loureiro, Miriam S. Reuter, Delnaz Roshandel, Joe Whitney, Mehdi Zarrei, Matthew Bookman, Cherith Somerville, Rulan Shaath, Mona Abdi, , Evdokia A. Anagnostou

This study identifies 135 ASD-associated protein-coding genes using whole-genome sequencing data from 11,312 individuals and exome sequencing from over 18,000 trios, with a false discovery rate of 80%.

medRxiv · May 5, 2022 · PreprintGenetic & Genomic Medicine

A cystic fibrosis lung disease modifier locus harbors tandem repeats associated with gene expression

Delnaz Roshandel, Scott Mastromatteo, Cheng Wang, Jiafen Gong, Bhooma Thiruvahindrapuram, Wilson W. L. Sung, Zhuozhi Wang, Omar Hamdan, Joe Whitney, Naim Panjwani, Fan Lin, Katherine Keenan, Angela Chen, Mohsen Esmaeili, Anat Halevy, , Lisa J. Strug

The paper identifies VNTRs near SLC9A3 associated with gene expression in CF nasal epithelia and shows their utility in explaining GWAS signals.

medRxiv · Mar 28, 2022 · PreprintGenetic & Genomic Medicine

Clinical genetic risk variants inform a functional protein interaction network for tetralogy of Fallot

Miriam S. Reuter, Rajiv R Chaturvedi, Rebekah Jobling, Giovanna Pellecchia, Omar Hamdan, Wilson W. L. Sung, Thomas Nalpathamkalam, Pratyusha Attaluri, Candice K. Silversides, Rachel Maya Wald, Christian R. Marshall, Simon G. Williams, Bernard D. Keavney, Bhooma Thiruvahindrapuram, Stephen W. Scherer, Anne S. Bassett

The paper identifies clinically relevant genetic variants in TOF patients and constructs a protein interaction network linking these variants to disease mechanisms.

Circulation Genomic and Precision Medicine · Jul 30, 2021Peer-reviewedGenetic & Genomic Medicine