Marieke Klein

This paper investigates the shared genetic architecture of psychiatric and insulin resistance conditions using multivariate GWAS and identifies potential biological mechanisms and drug candidates.

This study identifies EHMT1/G9a's role in sleep regulation through ROS homeostasis in insulin-producing cells, linking it to sleep disturbances in Kleefstra syndrome and common insomnia.

The paper examines how gene dosage, polygenic background, and environment influence complex traits like height and BMI using large-scale data from multiple cohorts.

The paper establishes a normative reference for large-scale human brain dynamics using resting-state fMRI data from over 10,000 individuals, revealing systematic reorganization across development and ageing and disorder-specific deviations in mental health conditions.

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

This study shows that autism spectrum disorder risk is influenced by rare variants, polygenic risk, and sex, with sex-specific effects on genetic liability and behavioral traits.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

This study identifies genetic influences on hub connectivity in the human connectome using diffusion-weighted imaging in twins and transcriptomic data.

This study identifies shared genetic loci between ADHD, aggressive behaviors, and antisocial behaviors using GWAS and gene-based analyses.

The paper analyzes sex differences in brain structure variability across the lifespan using a large dataset, finding greater male variability in subcortical volumes, cortical surface area, and thickness in most regions.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

This study analyzes subcortical volume changes across the lifespan using MRI data from 18,605 individuals, finding age-related declines in some structures and increases in others.

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

This study identifies ADHD risk genes by linking ID-related genes to ADHD through common variants and validates their role in Drosophila behavior.

This study identifies dopaminergic signaling as a genetic link between ADHD and obesity through genome-wide analyses and brain volume associations.

This study identifies high-priority ADHD candidate genes by integrating rare CNV data with bioinformatics methods and finds shared genes with common variants.

The paper identifies genetic correlations between ADHD and brain volumes, finding negative associations with intracranial volume and specific brain regions.

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.