Decoupled degradation and translation enables noise-modulation by poly(A)-tails
Carmen Grandi, Martin Emmaneel, Frank H. T. Nelissen, Laura W.M. Roosenboom, Yoanna Petrova, Omnia Elzokla, Maike M. K. Hansen
The paper examines how poly(A)-tail length affects mRNA degradation and translation in human cells, finding that optimal tail length maximizes translation and that variability in tail length modulates expression noise.
Cell Systems · Jun 1, 2024Peer-reviewedMolecular Biology