Maike M. K. Hansen

The paper identifies 32 putative noise regulators, including SON, which modulate transcriptional noise without affecting mean expression levels and influence cell fate decisions in mouse embryonic stem cells.

The paper examines how poly(A)-tail length affects mRNA degradation and translation in human cells, finding that optimal tail length maximizes translation and that variability in tail length modulates expression noise.

The paper shows that mRNA degradation, not just regulatory mechanisms, drives co-expression correlations in single-cell RNA sequencing data.

The paper develops ARTseq-FISH to study how micropattern position affects gene expression in mESCs, finding early position-dependent changes in mRNA and protein levels.

The paper shows TASOR interacts with CNOT1 and other RNA degradation factors to repress HIV expression by promoting RNA degradation and H3K9me3 deposition.

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

The paper investigates how HIV's Tat protein generates bimodal expression through non-latching positive feedback, decoupling noise from mean expression to maintain stochastic bimodality.