CSF infusion of TrkB agonist, 7,8-dihydroxyflavone, is ineffective in promoting remyelination in cuprizone and EAE models of multiple sclerosis
Jessica L. Fletcher, Rhiannon J. Wood, Alexa R Prawdiuk, Ryan O’Rafferty, Ophelia Ehrlich, David G. Gonsalvez, Simon S. Murray
This study shows that infusing the TrkB agonist 7,8-dihydroxyflavone into the cerebrospinal fluid does not promote myelin repair in cuprizone or EAE models of multiple sclerosis.
bioRxiv · Apr 19, 2021 · PreprintNeuroscience