David G. Gonsalvez

This study shows that rescuing Schwann cells in an ALS mouse model improves myelin structure but not motor function, highlighting the complex role of Schwann cells in disease progression.

This paper describes a human iPSC-derived organoid system that models myelin destruction and repair by incorporating mature oligodendrocytes and reactive microglia.

This study shows that cortical hyperexcitability in mice leads to ALS-like motor symptoms and pathology through a dying-forward mechanism.

This study shows that infusing the TrkB agonist 7,8-dihydroxyflavone into the cerebrospinal fluid does not promote myelin repair in cuprizone or EAE models of multiple sclerosis.

This study shows environmental enrichment stimulates structural remodeling of pre-existing myelinated axons and oligodendrocytes in young adult mice, increasing axon diameter and myelin thickness without enhancing new myelin production.

The paper compares oligodendrocyte generation dynamics in mice and humans, finding that mouse precursors do not vary division times and that murine oligodendrogenesis resembles human patterns.

This study shows that a BDNF mimetic targeting TrkB promotes myelin repair in a mouse model of demyelination by enhancing oligodendrocyte differentiation and remyelination.