Jessica L. Fletcher

This study shows that mice lacking CerS2 in oligodendrocytes develop myelin instability, microglial activation, and early lethality due to reduced C22-C24 sphingolipids.

This study shows that infusing the TrkB agonist 7,8-dihydroxyflavone into the cerebrospinal fluid does not promote myelin repair in cuprizone or EAE models of multiple sclerosis.

This study shows that acute treatment with TrkB agonist LM22A-4 after pediatric TBI reduces tissue damage and preserves myelin integrity, with some behavioral improvements.

This study shows environmental enrichment stimulates structural remodeling of pre-existing myelinated axons and oligodendrocytes in young adult mice, increasing axon diameter and myelin thickness without enhancing new myelin production.

This study compares two TrkB agonists, TDP6 and LM22A-4, in a mouse model of demyelination, finding that LM22A-4 promotes remyelination via indirect Trk receptor transactivation.

This study shows that a BDNF mimetic targeting TrkB promotes myelin repair in a mouse model of demyelination by enhancing oligodendrocyte differentiation and remyelination.