CAR T-cells dysfunction in the central nervous system is mediated by BBB-induced activation-induced cell death
Yarden Aharony-Tevet, Orly Ravid, Asaf David Yanir, Amilia Meir, Hadar Levi, Daniel Burstein, Aviya Amram, Tamar Feuerstein, Shai Izraeli, Itzik Cooper, Elad Jacoby
The paper investigates CAR T-cell dysfunction in the CNS, identifying BBB-induced activation-induced cell death as a mechanism of resistance.
bioRxiv · Oct 21, 2025 · PreprintCancer Biology