Shai Izraeli

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma

This paper develops a mutation-independent liquid biopsy method using DNA methylation to monitor high-risk neuroblastoma through blood plasma-derived cfDNA.

Context-dependent determinants of CRISPR-Cas9 editing efficiency revealed through cross-species endogenous editing analysis

The paper identifies context-dependent factors affecting CRISPR-Cas9 editing efficiency across species using endogenous editing data and shows that repair outcomes are conserved.

CAR T-cells dysfunction in the central nervous system is mediated by BBB-induced activation-induced cell death

The paper investigates CAR T-cell dysfunction in the CNS, identifying BBB-induced activation-induced cell death as a mechanism of resistance.

Towards accesible brain-tumor classification at the point of care Nanopore methylation sequencing from Formalin Fixed Paraffin Embedded (FFPE) pathology samples

This paper develops a validated protocol for using Oxford Nanopore methylation sequencing on FFPE samples to classify brain tumors, enabling point-of-care diagnosis.