Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
Samuel J. Connell, Sydney B. Crotts, Ryan J. Reis, Maddison Lensing, Payton Kahl, N. Henderson, Otgonzaya Ayush, Zhaowen Zhu, Luana dos Santos Ortolan, Audrey C. Ko, Erin M. Shriver, Keith D. Carter, John T. Harty, Joan M. Goverman, Ali Jabbari
This study shows that Th1 effector CD4 T cells produce IFN-γ to drive alopecia areata in mice, highlighting their pathogenic role and dependence on CD8 T cells and IFN-γ responsiveness.
Science Advances · Oct 31, 2025Peer-reviewedImmunology