John T. Harty

Longitudinal analysis reveals myeloid cell contributions to neuroPASC pathogenesis

This study uses longitudinal single-cell RNA sequencing to show that myeloid cells contribute to sustained neuroinflammation in neuroPASC, with microglia playing a central role.

Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata

This study shows that Th1 effector CD4 T cells produce IFN-γ to drive alopecia areata in mice, highlighting their pathogenic role and dependence on CD8 T cells and IFN-γ responsiveness.

mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria

This study shows that an mRNA vaccine can overcome hemozoin-mediated impairment of RAS vaccine efficacy in malaria-exposed mice by restoring CD8+ T cell responses and protection.

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria

This study identifies two IFN-I-driven hepatocyte antimicrobial programs that control liver-stage malaria by inducing GBPs and lysosomal defense mechanisms.

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

Antigen presentation by discrete class I molecules on brain endothelium dynamically regulates T-cell mediated neuropathology in experimental cerebral malaria

This study shows that specific MHC class I molecules on brain endothelium regulate CD8 T cell activity and neuropathology in experimental cerebral malaria.