Soluble, but not precursor EGF induces intracrine signaling of the EGFR
Noémi Bilakovics, Julianna Volkó, Chinzorig Jeppesen, Gergely József Fekete, István Csomós, Andrea Bodnár, Gábor Mocsár, Krisztína Németh, Attila Kormos, Katalin Tóth, György Vereb, Pál Nagy, György Vámosi
The paper shows that soluble EGF (sEGF) induces intracrine EGFR signaling in the Golgi, while preEGF does not, and that this signaling is inhibited by erlotinib but not cetuximab.
bioRxiv · Nov 28, 2025 · PreprintBiophysics