Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation
Kristiina Rajamäki, Salla Keskitalo, Mikko R. J. Seppänen, Outi Kuismin, Paula Vähäsalo, Luca Trotta, Antti Väänänen, Virpi Glumoff, Paula L. Keskitalo, Riitta L. Kaarteenaho, Airi E. Jartti, Nina Maria Hautala, Päivi Jackson, Dan Nordström, Janna Saarela, , Markku T Varjosalo
This study identifies a novel mutation in A20 causing haploinsufficiency and shows it impairs the protein-protein interactome, leading to enhanced NLRP3 inflammasome activation through caspase-8.
RMD Open · Oct 1, 2018Peer-reviewedMolecular Biology