Salla Keskitalo

This paper describes a method to obtain brain tissue for omic analyses using SEEG electrodes, showing concordant transcriptomic and proteomic findings across different epileptic zones.

The paper identifies a phosphorylation switch in PAGE4 as a key mechanism in MED12-mutant fibroid pathogenesis, revealing its role in rewiring the interactome and transcriptional machinery.

The paper compares plasma protein enrichment methods, finding MagNet significantly increases protein identifications and enables cost-effective, high-throughput LC-MS proteomics.

This study identifies POLE2 as a general NPF-motif receptor, revealing its role in recruiting proteins involved in replication, DNA repair, and transcription through SLiM-mediated interactions.

This study shows ISG15 modulates Clade Ib and II MPXV infection differently in MEF cells, with clade-specific effects on viral replication and immune evasion.

This paper presents a T cell gene correction pipeline using CRISPR/Cas9 and HDR to correct monogenic mutations in IEI models, achieving up to 80% bi-allelic editing with no detectable off-target effects.

This study shows that resistance training induces reversible and retained proteomic changes in human skeletal muscle, suggesting a proteomic memory of muscle growth.

The paper maps the interactome and substrates of human receptor tyrosine kinases using AP-MS, BioID, and kinase assays, revealing interactions and functions of both well-known and understudied RTKs.

The paper evaluates DNA repair protein-Cas9 fusions for improving CRISPR editing efficiency, finding that most require optimization for specific cell types and genomic loci.

This study identifies a novel mutation in A20 causing haploinsufficiency and shows it impairs the protein-protein interactome, leading to enhanced NLRP3 inflammasome activation through caspase-8.