Author

Mikko R. J. Seppänen

University of HelsinkiORCID 0000-0001-9733-3650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Airi E. Jartti· 1 shared Antti Väänänen· 1 shared Dan NordströmiD· 1 shared Janna SaarelaiD· 1 shared Kari K. EklundiD· 1 shared Kristiina RajamäkiiD· 1 shared Luca TrottaiD· 1 shared Markku T VarjosaloiD· 1 shared

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2018-2018 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Airi E. Jartti

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1 paper

Recent·Most cited

Molecular BiologyRMD OpenPeer-reviewedOct 1, 2018

Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

Kristiina Rajamäki, Salla Keskitalo, Mikko R. J. Seppänen…·Markku T Varjosalo

This study identifies a novel mutation in A20 causing haploinsufficiency and shows it impairs the protein-protein interactome, leading to enhanced NLRP3 inflammasome activation through caspase-8.

34 citations

humanproteomics

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