BioengineeringbioRxiv
Transferrin Receptor Targeting Chimeras (TransTACs) for Membrane Protein Degradation
D. Zhang, J. Duque-Jimenez, G. Brixi…·X. Zhou
This paper introduces TransTACs, a method for degrading membrane proteins by redirecting them to lysosomal degradation using the transferrin receptor, showing high efficiency across various protein types.
DOI 10.1038/s41586-024-07947-3