Allometric tissue-scale forces activate mechanoresponsive immune cells to drive pathological foreign body response to biomedical implants
J. Padmanabhan, K. Chen, D. Sivaraj, B. A. Kuehlmann, C. A. Bonham, T. Dohi, D. Henn, Z. A. Stern-Buchbinder, P. A. Than, H. S. Hosseini, J. A. Barrera, H. C. Kussie, N. J. Magbual, M. R. Borrelli, A. A. Trotsyuk, , G. C. Gurtner
The paper shows allometric tissue-scale forces drive pathological foreign body response by activating Rac2 signaling in immune cells, independent of implant properties.
bioRxiv · Jan 14, 2022 · PreprintBioengineering