Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.
N. Anghel, P. A. Winzer, D. Imhof, J. Mueller, X. Langa Oliva, J. Rieder, L. K. Barrett, R. S. R. V. Rao Vidadala, W. Huang, R. Choi, M. Hulverson, G. Whitman, S. Arnold, W. Van Voorhis, K. K. Ojo, , A. Hemphill
This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.
International Journal of Antimicrobial Agents · Sep 1, 2020Peer-reviewedPathology