HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
J. Cao, L. Sun, P. Aramsangtienchai, N. A. Spiegelman, X. Zhang, E. Seto, H. Lin
This study identifies HDAC11 as a defatty-acylase that regulates type I interferon signaling by modifying SHMT2, revealing a novel function of HDAC11 beyond its deacetylase activity.
bioRxiv · Oct 31, 2017Biochemistry