P. Ashcroft

Constrained optimisation of divisional load in hierarchically-organised tissues during homeostasis

The paper develops a mathematical model to optimise divisional load in hierarchical tissues during homeostasis, finding that binary division trees with non-self-renewing progenitors minimise mutation risk.

Stochastic gene expression influences the selection of antibiotic resistance mutations

This study shows stochastic gene expression affects the selection of antibiotic resistance mutations, with regulatory and structural mutations providing different resistance mechanisms.

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

The paper models how timing of aromatase inhibitor and immune checkpoint inhibitor therapies affects tumor burden and metastatic potential in hormone receptor positive breast cancer.