R. Bravo

Spatial interactions modulate tumor growth and immune infiltration

This study uses computational modeling to explore how spatial interactions between immune cells and collagen fibers influence tumor growth and immune infiltration.

Bibliometric analysis on cannibalism/infanticide and maternal aggression towards pups in laboratory animals

This study compares scientific interest in cannibalism/infanticide and maternal aggression in laboratory animals using bibliometric analysis, finding they are distinct but share some common features.

Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation

This paper presents a multiscale mathematical model of tumor-immune interactions that identifies metaphenotypes driving immune escape and metabolic transformation in cancer.

Modeling adaptive therapy in non-muscle invasive bladder cancer

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

How Homeostasis Limits Keratinocyte Evolution

This study presents a mechanistic epidermal model showing homeostasis leads to log-linear subclone size distributions in skin cells, with larger subclones being older due to persistence of driver mutations.

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

The paper models how timing of aromatase inhibitor and immune checkpoint inhibitor therapies affects tumor burden and metastatic potential in hormone receptor positive breast cancer.