Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms
M. Kelkar, P. Bohec, M. Smith, V. Sreenivasan, A. Lisica, L. Valon, E. Ferber, B. Baum, G. Salbreux, G. Charras
The paper investigates how mitotic spindles reorient in response to mechanical stress and finds that spindle rotation emerges from interactions between positioning machinery and cortical tension.
bioRxiv · Feb 13, 2022Cell Biology