Author

P. Calligari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Organism:zebrafish· 1

Frequent Co-Authors

G. Bocchinfuso· 2 shared L. Stella· 2 shared M. Tartaglia· 2 shared A. Bocedi· 1 shared A. Lauri· 1 shared A. Quercioli· 1 shared B. Biondi· 1 shared C. De Faveri· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

G. Bocchinfuso

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2 papers

Recent·Most cited

Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions

S. Bobone, L. Pannone, B. Biondi, M. Solman, E. Flex, V. Canale, P. Calligari, C. De Faveri, T. Gandini, A. Quercioli, G. Torini, M. Venditti, A. Lauri, G. Fasano, J. Hoeksma, , L. Stella

This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.

bioRxiv · Aug 28, 2020Biophysics

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

M. Anselmi, P. Calligari, J. S. Hub, M. Tartaglia, G. Bocchinfuso, L. Stella

This study uses molecular dynamics simulations to analyze the structural determinants of phosphopeptide binding to the N-SH2 domain of SHP2, identifying key residues and interactions that influence binding affinity and specificity.

bioRxiv · Mar 27, 2020Biophysics