Author

M. Tartaglia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Bocchinfuso· 2 shared L. Stella· 2 shared P. Calligari· 2 shared A. A. d. J. Rasheed· 1 shared A. Bocedi· 1 shared A. Borchardt· 1 shared A. Hahn· 1 shared A. Iannuzzo· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

G. Bocchinfuso

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation

A. Iannuzzo, S. Delafontaine, R. El Masri, R. Tacine, G. Prencipe, M. Nishitani-Isa, R. T. van Wijck, F. Bhuyan, A. A. d. J. Rasheed, S. Coppola, P. L. van Daele, A. Insalaco, R. Goldbach-Mansky, T. Yasumi, M. Tartaglia, , J. Delon

This study identifies Golgi-trapped CDC42 variants causing STING hyperactivation and IFN elevation in autoinflammatory patients.

bioRxiv · Jan 31, 2024 · PreprintImmunology

Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

S. Nakhaei-Rad, F. Bazgir, J. Dahlmann, A. V. Busley, M. Buchholzer, F. Haghighi, A. Schaenzer, A. Hahn, S. Koetter, D. Schanze, R. Anand, F. Funk, A. Borchardt, A. V. Kronenbitter, J. Scheller, , M. R. Ahmadian

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

bioRxiv · Jan 22, 2022 · PreprintCell Biology

Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions

S. Bobone, L. Pannone, B. Biondi, M. Solman, E. Flex, V. Canale, P. Calligari, C. De Faveri, T. Gandini, A. Quercioli, G. Torini, M. Venditti, A. Lauri, G. Fasano, J. Hoeksma, , L. Stella

This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.

bioRxiv · Aug 28, 2020Biophysics

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

M. Anselmi, P. Calligari, J. S. Hub, M. Tartaglia, G. Bocchinfuso, L. Stella

This study uses molecular dynamics simulations to analyze the structural determinants of phosphopeptide binding to the N-SH2 domain of SHP2, identifying key residues and interactions that influence binding affinity and specificity.

bioRxiv · Mar 27, 2020Biophysics