Mechanical force regulates ligand binding and function of PD-1
K. Li, P. Cardenas-Lizana, A. V. Kellner, Z. Yuan, E. Ahn, J. Lyu, Z. Li, K. Salaita, R. Ahmed, C. Zhu
This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.
Nature Communications · Sep 27, 2024Peer-reviewedImmunology