R. Ahmed

Mechanical force regulates ligand binding and function of PD-1

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.

Exploiting gene expression profiles of circulating extracellular vesicles for breast cancer detection

This study identifies five circulating extracellular vesicle RNAs that can diagnose breast cancer independently of subtypes and detect metastatic states.

Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates

This study uses NMR to show CAPRIN1 condensates shift SOD1 folding towards unfolded states, promoting aggregation, while a zinc-bound dimeric form is more stable.

Functional impairment of "helpless" CD8+ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

Assessing variation in Citrus limon "Assam lemon": morphological, seed availability pattern, and biochemical diversity across different districts of Assam

This study examines morphological, seeding, and biochemical diversity in Assam lemon populations across 22 districts in India, revealing clustering patterns and seedless trait distribution.

Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs

The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

Genome-wide investigation of Cytochrome P450 superfamily of Aquilaria agallocha: association with terpenoids and phenylpropanoids biosynthesis

This study identifies and characterizes CYPs in Aquilaria agallocha, linking them to terpenoids and phenylpropanoids biosynthesis and validating their expression in stress-induced tissues.

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells

This study investigates how different routes of self-amplifying mRNA vaccination affect the establishment of pulmonary resident memory T cells in mice.

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

The paper develops a method to deliver mRNA to multiple virus-specific T cells using light-induced ligand exchange of MHC class I antigen-presenting nanoparticles, achieving ~50% transfection in vivo.

Molecular evolution and genetic analysis of Mesta yellow vein mosaic virus and associated betasatellites

This study analyzes the molecular evolution and genetic diversity of Mesta yellow vein mosaic virus and its associated betasatellites in the Indian subcontinent, identifying recombination, selection pressures, and geographic influences on their evolution.

The CD8+ T cell landscape of human brain metastases

This study characterizes CD8+ T cell phenotypes and spatial distribution in brain metastases using single-cell RNA-sequencing and spatial transcriptomics, revealing distinct subpopulations and their functional states.

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

Niclosamide inhibits SARS-CoV2 entry by blocking internalization through pH-dependent CLIC/GEEC endocytic pathway

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

Prevalence of Diversified Antibiotic Resistant Bacteria within Sanitation Related Facilities of Human Populated Workplaces in Abbottabad

This study assesses multi-drug resistant bacteria in sanitation facilities of human workplaces, finding resistance patterns linked to isolation sources and plasmid-mediated resistance.