Author

P. Close

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

F. Rapino· 2 shared L. Geris· 2 shared M. Joiret· 2 shared A. Blomme· 1 shared C. A. Ford· 1 shared C. Nixon· 1 shared C. Ntala· 1 shared C. Peter· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

F. Rapino

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3 papers

Recent·Most cited

A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome

M. Joiret, F. Rapino, P. Close, L. Geris

The paper develops a geometrical model to estimate the electrostatic potential and field around the ribosome's peptidyl transferase center and assesses its role in peptide bond formation.

bioRxiv · Mar 7, 2022 · PreprintBiophysics

THEM6-mediated lipid remodelling sustains stress resistance in cancer

A. Blomme, C. Peter, E. Mui, G. Rodriguez Blanco, L. M. Mason, L. E. Jamieson, G. H. McGregor, S. Lilla, C. Ntala, R. Patel, M. Thiry, S. H. Kung, C. A. Ford, L. K. Rushworth, D. J. McGarry, , H. Y. Leung

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

bioRxiv · Apr 4, 2021Cancer Biology

Ribosome Exit Tunnel Electrostatics

M. Joiret, F. Rapino, P. Close, L. Geris

This paper develops a quantitative electrostatic model of the ribosome exit tunnel to analyze its impact on protein elongation rates and forces on nascent polypeptides.

bioRxiv · Oct 20, 2020 · PreprintBiophysics