Author

G. H. McGregor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:metabolomics· 2 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

R. S. Kuna· 2 shared T. Cordes· 2 shared A. Blomme· 1 shared A. Kumar· 1 shared C. A. Ford· 1 shared C. M. Metallo· 1 shared C. Metallo· 1 shared C. Nixon· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

R. S. Kuna

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Author profile →

3 papers

Recent·Most cited

Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

R. S. Kuna, A. Kumar, K. A. Wessendorf-Rodriguez, H. Galvez, C. R. Green, G. H. McGregor, T. Cordes, R. J. Shaw, R. U. Svensson, C. Metallo

The paper investigates how acetyl-CoA homeostasis and lipogenesis are maintained under metabolic stress through inter-organelle crosstalk using isotope tracing in knockout cell lines.

bioRxiv · Sep 24, 2022 · PreprintBiochemistry

1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

T. Cordes, R. S. Kuna, G. H. McGregor, S. V. Khare, J. Gengatharan, T. Muthusamy, C. M. Metallo

This study shows that 1-deoxysphingolipid synthesis, driven by SPT promiscuity, impairs anchorage-independent growth and plasma membrane endocytosis in cancer cells.

bioRxiv · Jan 19, 2022 · PreprintCancer Biology

THEM6-mediated lipid remodelling sustains stress resistance in cancer

A. Blomme, C. Peter, E. Mui, G. Rodriguez Blanco, L. M. Mason, L. E. Jamieson, G. H. McGregor, S. Lilla, C. Ntala, R. Patel, M. Thiry, S. H. Kung, C. A. Ford, L. K. Rushworth, D. J. McGarry, , H. Y. Leung

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

bioRxiv · Apr 4, 2021Cancer Biology