Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP
A. P. Z. P. Fiore, A. M. R. da Silva, H. V. Ribeiro, A. C. Manucci, P. d. F. Ribeiro, M. C. Silva Botelho, P. S. L. Oliveira, M. Pagano, A. Bruni-Cardoso
This study shows that ECM stiffness promotes MST2 degradation via SCFβTrCP ubiquitination, affecting YAP nuclear localization and mechanoregulated processes in breast epithelial cells.
bioRxiv · Jan 31, 2021 · PreprintCell Biology