M. Pagano

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

This paper introduces PHOIMiDs, photoswitchable immunomodulatory drugs that degrade Ikaros and Aiolos in a light-dependent manner with high selectivity.

Matters Arising: FBXO38 does not control PD-1 stability

This study investigates whether FBXO38 regulates PD-1 stability in T cells and finds no evidence supporting this claim.

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

This study identifies FBXL4 as a suppressor of basal mitophagy by ubiquitylating and degrading NIX and BNIP3, and shows pathogenic variants disrupt this function leading to mtDNA depletion syndrome.

Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP

This study shows that ECM stiffness promotes MST2 degradation via SCFβTrCP ubiquitination, affecting YAP nuclear localization and mechanoregulated processes in breast epithelial cells.

Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation

The paper identifies a cyclin A-specific interaction between SKP2 and CDK2-cyclin A complexes that promotes p27KIP1 degradation, distinguishing cyclin A from other G1 cyclins.

Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

The paper investigates genome-wide uracil distribution changes in human cells after chemotherapy, finding drug-induced shifts toward active genomic regions.

The ULK1-FBXW5-SEC23B nexus controls autophagy

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.