Ubiquitin Substrates Dramatically Increase Ataxin3 Deubiquitinating Activity: Allosteric crosstalk connects three distinct sites
M. V. Rao, K. C. Grasty, P. D. Mehetre, P. J. Loll
This study shows that ubiquitin conjugates significantly enhance ataxin3 deubiquitinating activity through allosteric interactions involving three distinct sites on the enzyme.
bioRxiv · May 5, 2020 · PreprintBiochemistry