Author

K. C. Grasty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. J. Loll· 3 shared J. Beld· 2 shared C. Guzik· 1 shared E. J. D'Lauro· 1 shared M. V. Rao· 1 shared N. Webber· 1 shared P. D. Mehetre· 1 shared P. J. Lee· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

P. J. Loll

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Author profile →

3 papers

Recent·Most cited

Novel Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins

P. Rotsides, P. J. Lee, N. Webber, K. C. Grasty, J. Beld, P. J. Loll

This paper develops diazirine-based vancomycin photoprobes with improved specificity and fewer chemical modifications for identifying vancomycin-binding proteins.

bioRxiv · Jun 15, 2023Biochemistry

Structure of VanS from Vancomycin-Resistant Enterococci: A Sensor Kinase with Weak ATP Binding

K. C. Grasty, C. Guzik, E. J. D'Lauro, S. B. Padrick, J. Beld, P. J. Loll

The paper presents X-ray structures of VanS CA domains from VRE types A and C, revealing weak ATP binding with low millimolar KD values, suggesting a regulatory mechanism for resistance gene expression.

bioRxiv · Dec 12, 2022Biochemistry

Ubiquitin Substrates Dramatically Increase Ataxin3 Deubiquitinating Activity: Allosteric crosstalk connects three distinct sites

M. V. Rao, K. C. Grasty, P. D. Mehetre, P. J. Loll

This study shows that ubiquitin conjugates significantly enhance ataxin3 deubiquitinating activity through allosteric interactions involving three distinct sites on the enzyme.

bioRxiv · May 5, 2020 · PreprintBiochemistry