MicrobiologybioRxiv
Mechanistic insights into dideoxygenation in gentamicin biosynthesis
S. Li, P. d. S. Bury, F. Huang…·Y. Sun
The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.
DOI 10.1021/acscatal.1c03508