A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset
P. Dadova, A. Mikulova, R. Jarousek, S. Uldrijan, L. Kubala
This study shows that forskolin increases cAMP, promoting Th1 and Th2 differentiation while suppressing Th17, with CXCL13 upregulation and reversible effects by a cAMP inhibitor.
bioRxiv · Jun 26, 2022Cell Biology