TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
M. Perez-Berlanga, V. I. Wiersma, A. Zbinden, L. De Vos, U. Wagner, C. Foglieni, I. Mallona, K. M. Betz, A. Clery, J. Weber, Z. Guo, R. Rigort, P. de Rossi, R. Manglunia, E. Tantardini, , M. Polymenidou
This study shows TDP-43 oligomerization and RNA binding work together to control its stability and localization, and their loss leads to different pathological outcomes.
bioRxiv · May 23, 2022 · PreprintCell Biology