Evolution of the CRISPR-Cas9 defence system in Mycoplasma gallisepticum following colonization of a novel bird host
T. Ipoutcha, I. Tsarmpopoulos, G. Gourgues, V. Baby, P. Dubos, G. E. Hill, Y. Arfi, C. Lartigue, P. Thebault, C. Bonneaud, P. Sirand-Pugnet
This study tracks the evolution of CRISPR-Cas9 in Mycoplasma gallisepticum after it shifted to a novel bird host, showing changes in spacers and PAM recognition, and a loss of CRISPR-Cas function over time.
bioRxiv · Mar 14, 2023 · PreprintMicrobiology