Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening
A. K. Singh, S. E. Martinez, W. Gu, H. Nguyen, D. Schols, P. H. Herdewijn, S. De Jonghe, K. Das
The paper identifies a transient P-pocket in HIV-1 reverse transcriptase during DNA sliding and demonstrates fragment screening to target this pocket for inhibitor development.
bioRxiv · Jul 3, 2021Biophysics