Author

P. H. Smeele

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Neuroscience· 1

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Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Poletti· 1 shared E. Dona'· 1 shared G. Spina· 1 shared R. Cauchi· 1 shared Thomas VaccariiD· 1 shared V. Ferrari· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperNeuroscience

A. Poletti

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1 paper

Recent·Most cited

Pharmaco-genetic evidence of presymptomatic lysosomal dysfunction coupled to detrimental DPR secretion in Drosophila Models of C9orf72-linked ALS/FTD.

P. H. Smeele, V. Ferrari, G. Spina, E. Dona', R. Cauchi, A. Poletti, Thomas Vaccari

This study shows that C9orf72 repeat expansions cause presymptomatic lysosomal dysfunction in Drosophila, leading to DPR secretion and neurotoxicity, which can be mitigated by valproic acid.

bioRxiv · Nov 10, 2026 · PreprintNeuroscience