Interplay between mitochondria and reactive oxygen and nitrogen species in metabolic adaptation to hypoxia in facioscapulohumeral muscular dystrophy: potential therapeutic targets.
P. Heher, M. Ganassi, A. Weidinger, E. N. Engquist, J. Pruller, T. H. Nguyen, A. Tassin, A. E. Decleves, K. Mamchaoui, J. Grillari, A. Kozlov, P. S. Zammit
This paper investigates how mitochondrial reactive oxygen and nitrogen species (RONS) metabolism contributes to oxidative stress in FSHD, showing that mitochondria-targeted antioxidants are more effective in rescuing pathology.
bioRxiv · Sep 8, 2021 · PreprintPathology