K. Mamchaoui

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformations

This study uses microgroove substrates to show that adherent cells exhibit dynamic 3D nuclear deformations driven by adhesion, with implications for diagnosing nuclear mechanical disorders.

Dystrophin is a mechanical tension modulator

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

Interplay between mitochondria and reactive oxygen and nitrogen species in metabolic adaptation to hypoxia in facioscapulohumeral muscular dystrophy: potential therapeutic targets.

This paper investigates how mitochondrial reactive oxygen and nitrogen species (RONS) metabolism contributes to oxidative stress in FSHD, showing that mitochondria-targeted antioxidants are more effective in rescuing pathology.

Myogenin controls via AKAP6 non-centrosomal microtubule organizing center formation at the nuclear envelope

The paper identifies myogenin's role in inducing AKAP6 and nesprin-1 to form non-centrosomal MTOCs at the nuclear envelope in muscle cells.

Lamin-related congenital muscular dystrophy alters mechanical signaling and skeletal muscle growth

This study investigates how LMNA mutations affect skeletal muscle growth and mechanical signaling in muscle stem cells and mouse models, finding impaired differentiation and hypertrophy in LMNA-CMD.