T. H. Nguyen

This study identifies IRF-5 as essential for maintaining mitochondrial function and oxidative phosphorylation in CD8 T cells during chronic LCMV Cl13 infection, preventing functional exhaustion and cell death.

The paper develops a model combining tumor-specific methylation atlas and cfDNA features to improve tissue-of-origin detection in low-depth cfDNA samples.

This paper reviews empirical studies on root hydraulic properties across scales, identifies factors influencing their variability, and highlights the importance of root system age and measurement conditions.

This study shows that Prom1 and Ttyh1 both induce extracellular vesicle formation, with Ttyh1 producing more tubulated vesicles and showing stronger cholesterol binding.

The paper tests non-antibiotic drugs' effects on gut microbiome composition and finds some increase Salmonella abundance, potentially increasing infection risk.

This study uses a GFP-reporter library to profile Salmonella transcriptional dynamics during macrophage infection, revealing condition-specific regulation and novel gene activity.

The paper determines the structure of VP39, a baculovirus capsid protein, revealing its assembly into a helical tube and conserved fold across species.

This study shows that gut microbiota assembly follows 'early-bird' dynamics where fast-growing species dominate nutrient sources, and develops a predictive model for community composition based on nutrient inputs.

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

This study develops a framework to distinguish resource competition from other interactions in gut bacterial communities, showing it explains most pairwise interactions and predicts community assembly.

The paper constructs an ordered mutant collection of Bacteroides thetaiotaomicron using transposon-insertion and barcode sequencing, identifies factors limiting coverage, and demonstrates phenotypic screening for growth defects and cell shape changes.

This paper shows grape seed extract (GSE) is more effective than chemical disinfectants at inactivating Tulane virus, a human norovirus surrogate, by causing virus aggregation.

This paper investigates how mitochondrial reactive oxygen and nitrogen species (RONS) metabolism contributes to oxidative stress in FSHD, showing that mitochondria-targeted antioxidants are more effective in rescuing pathology.

The paper investigates how cardiolipin distribution affects mitochondrial inner membrane fusion mediated by Opa1, finding that cardiolipin in the outer leaflet is crucial for tethering and fusion.

This study identifies OsK5.2, an outward K+ channel, as a key determinant of rice salt tolerance by facilitating K+ translocation and reducing Na+ accumulation in leaves.

This study shows that ATM activation due to telomere dysfunction causes chemoresistance in ALT neuroblastoma, which can be reversed by the ATM inhibitor AZD0156.

This study examines within-host evolutionary dynamics of seasonal and pandemic influenza A viruses in young children, finding that nonsynonymous mutations decrease over time in A/H1N1pdm09 but increase in A/H3N2 due to mutation-selection balance.

This work proposes a rapid (<1 min.), label-free testing method for SARS-CoV-2 detection using quantitative phase imaging and deep learning with 96% accuracy.

The paper demonstrates a method to decontaminate N-95 respirators using a modified microwave oven, achieving significant viral and bacterial reduction without damaging the respirators.

This study develops a high-throughput method to cultivate diverse, stable fecal-derived microbial communities in vitro, demonstrating their utility for modeling the intestinal microbiota and predicting in vivo responses to antibiotics.

This paper introduces a Bayesian framework for analyzing ITC data to better estimate thermodynamic parameters and their uncertainties.

This paper introduces a label-free method using SLIM to detect breast cancer with high sensitivity and specificity by analyzing tissue nanostructure.