Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement of neutrophils under flow
A. Dupuy, C. Aponte Santamaria, A. Yeheskel, F. Gräter, P. J. Hogg, F. H. Passam, J. Chiu
This study identifies PDI-mediated cleavage of a disulfide bond in Mac-1 as a mechanism enabling neutrophil directional movement under flow by promoting de-adhesion from ICAM-1.
bioRxiv · Mar 29, 2022Biochemistry