K. M. Cook

Intermittent hypoxia enhances the expression of HIF1A by increasing the quantity and catalytic activity of KDM4A-C and demethylating H3K9me3 at the HIF1A locus

This study shows intermittent hypoxia increases HIF1A expression by boosting KDM4A-C activity, which demethylates H3K9me3 at the HIF1A locus, differing from chronic hypoxia effects.

C-terminal HSP90 Inhibitors Block the HSP90:HIF-1a Interaction and Inhibit the Cellular Hypoxic Response

This study shows C-terminal HSP90 inhibitors block HIF-1 stabilization under hypoxia, leading to HIF-1 degradation and reduced hypoxic gene expression in colorectal cancer cells.

Evaluation of a potential redox switch in blood coagulation tenase

This study investigates whether FVIII modulates the redox state of FIXa disulfide bonds in the tenase complex but finds no evidence of such regulation.