Author

P. J. Hosein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bianchi· 2 shared I. de Castro Silva· 2 shared J. Datta· 2 shared N. Merchant· 2 shared S. Mehra· 2 shared A. R. Dosch· 1 shared D. Kwon· 1 shared F. Messagio· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

A. Bianchi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Neutrophil-Mediated Stromal-Tumor IL-6/STAT-3 Signaling Underlies the Association between Neutrophil-to-Lymphocyte Ratio Dynamics and Chemotherapy Response in Localized Pancreatic Cancer: A Hybrid Clinical-Preclinical Study

I. de Castro Silva, P. Sharma, A. Bianchi, N. Deshpande, S. Mehra, J. England, P. J. Hosein, D. Kwon, N. Merchant, J. Datta

This study shows that neutrophil-to-lymphocyte ratio (NLR) dynamics predict chemotherapy response in pancreatic cancer and that targeting NLR improves chemosensitivity by modulating IL-6/STAT-3 signaling.

bioRxiv · May 4, 2022 · PreprintImmunology

Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer

J. Datta, X. Dai, A. Bianchi, I. De Castro Silva, S. Mehra, V. T. Garrido, P. Lamichhane, S. Singh, Z. Zhou, A. R. Dosch, F. Messagio, Y. Ban, O. Umland, P. J. Hosein, N. Nagathihalli, N. Merchant

This paper shows that combining MEK and STAT3 inhibitors reprograms stromal inflammation and enhances immunotherapy response in pancreatic cancer.

bioRxiv · Mar 7, 2021 · PreprintCancer Biology