Author

P. J. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

W. Nahrendorf· 2 shared A. Herbert Mainero· 1 shared A. Ivens· 1 shared C. Sutherland· 1 shared G. J. M. Cowan· 1 shared J. P. Mooney· 1 shared J. Thompson· 1 shared N. L. Smith· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

W. Nahrendorf

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Author profile →

3 papers

Recent·Most cited

The impact of innate immunity on malaria parasite infection dynamics

A. Herbert Mainero, P. J. Spence, S. E. Reece, T. Kamiya

This study performs a meta-analysis of rodent malaria parasite infection dynamics to assess the impact of innate immunity, finding small effect sizes and variability explained by stochasticity and experimental factors.

bioRxiv · Apr 17, 2023 · PreprintEvolutionary Biology

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

W. Nahrendorf, A. Ivens, P. J. Spence

This study shows that a single malaria infection can induce host adaptations that reduce inflammation and tissue damage, providing an alternative immunity strategy independent of pathogen load.

bioRxiv · Oct 1, 2020Immunology

A Conserved TCRβ signature dominates a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection

N. L. Smith, W. Nahrendorf, C. Sutherland, J. P. Mooney, J. Thompson, P. J. Spence, G. J. M. Cowan

The paper identifies a conserved TCRβ signature dominated by TRBV3 gene usage in a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection.

bioRxiv · Jul 27, 2020Immunology