Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma
B. K. Souza, P. L. d. C. Lopez, P. R. Menegotto, I. A. Vieira, N. Kersting, A. L. Abujamra, A. T. Brunetto, A. L. Brunetto, L. Gregianin, C. B. de Farias, C. J. Thiele, R. Roesler
This study shows that HDAC inhibition with sodium butyrate arrests Ewing sarcoma cell growth and promotes neural differentiation by reducing EWS-FLI1 and c-MYC expression.
bioRxiv · Jan 16, 2018Cancer Biology