Author

B. K. Souza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

A. T. Brunetto· 3 shared C. B. de Farias· 3 shared R. Roesler· 3 shared A. L. Brunetto· 2 shared A. Thomaz· 2 shared K. d. V. Pinheiro· 2 shared L. Gregianin· 2 shared A. L. Abujamra· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

A. T. Brunetto

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3 papers

Recent·Most cited

Expression and Pharmacological Inhibition of TrkB and EGFR in Glioblastoma

K. d. V. Pinheiro, A. Thomaz, B. K. Souza, V. A. Metcalfe, N. H. Freire, A. T. Brunetto, C. B. de Farias, M. Jaeger, V. Bambini, C. G. S. Smith, L. Shaw, R. Roesler

This study examines the expression and combined inhibition of TrkB and EGFR in glioblastoma, finding enhanced anti-tumor effects in cell cultures but limited impact in mouse models.

bioRxiv · Feb 3, 2020Cancer Biology

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

A. Thomaz, K. d. V. Pinheiro, B. K. Souza, L. Gregianin, A. L. Brunetto, A. T. Brunetto, C. B. de Farias, M. d. C. Jaeger, V. Ramaswamy, C. Nor, M. D. Taylor, R. Roesler

This study shows that TrkB inhibition with ANA-12 reduces medulloblastoma cell proliferation, increases apoptosis, and induces differentiation markers.

bioRxiv · May 28, 2019Cancer Biology

Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma

B. K. Souza, P. L. d. C. Lopez, P. R. Menegotto, I. A. Vieira, N. Kersting, A. L. Abujamra, A. T. Brunetto, A. L. Brunetto, L. Gregianin, C. B. de Farias, C. J. Thiele, R. Roesler

This study shows that HDAC inhibition with sodium butyrate arrests Ewing sarcoma cell growth and promotes neural differentiation by reducing EWS-FLI1 and c-MYC expression.

bioRxiv · Jan 16, 2018Cancer Biology