Dynamic in situ confinement triggers ligand-free neuropeptide receptor signaling
M. F. Sanchez, M. S. Dietz, U. Müller, J. Weghuber, K. Gatterdam, R. Wieneke, M. Heilemann, P. Lanzerstorfer, R. Tampe
This study shows that dynamic in situ confinement of the Y2R receptor triggers ligand-independent signaling through cytosolic calcium increases, cell spreading, and migration.
bioRxiv · Dec 15, 2021Biophysics